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Home > Curated Information Page > PubMed Id: 12093790
Gugasyan R, et al. (2002) Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites. J Cell Biol 158, 115-25 12093790
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y276-p - DOK2 (mouse)
Modsite: LPRPESPySRPHDSL SwissProt Entrez-Gene
Orthologous residues
DOK2 (human): Y271‑p, DOK2 (mouse): Y276‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  bone marrow, HEK293T (epithelial)
Cellular systems studied:  cell lines, primary cells
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell differentiation, altered, cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RASA1 (mouse) Induces co-immunoprecipitation

Y304-p - DOK2 (mouse)
Modsite: PGAPEGEyAVPFDTV SwissProt Entrez-Gene
Orthologous residues
DOK2 (human): Y299‑p, DOK2 (mouse): Y304‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  bone marrow, HEK293T (epithelial)
Cellular systems studied:  cell lines, primary cells
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell differentiation, altered, cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RASA1 (mouse) Induces co-immunoprecipitation

Y351-p - DOK2 (mouse)
Modsite: APLPDHIyDEPEGVA SwissProt Entrez-Gene
Orthologous residues
DOK2 (human): Y345‑p, DOK2 (mouse): Y351‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  bone marrow, HEK293T (epithelial)
Cellular systems studied:  cell lines, primary cells
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  cell differentiation, altered, cell growth, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NCK1 (mouse) Induces co-immunoprecipitation