Curated Information
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Home > Curated Information Page > PubMed Id: 26697860
Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K (2015) Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment. PLoS One 10, e0145441 26697860
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S133-p - CREB (rat)
Modsite: EILsRRPsYRkILND SwissProt Entrez-Gene
Orthologous residues
CREB (human): S119‑p, CREB iso1 (human): S133‑p, CREB (mouse): S119‑p, CREB iso1 (mouse): S133‑p, CREB (rat): S133‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
memantine decrease

T542-p - Tau (rat)
Modsite: KKVAVVRtPPKsPSA SwissProt Entrez-Gene
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso4 (human): T202‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PPP2CA (rat) decrease endogenous PPP2CA inhibitor
memantine augment treatment-induced decrease

S546-p - Tau (rat)
Modsite: VVRtPPKsPSASKsR SwissProt Entrez-Gene
Orthologous residues
Tau (human): S552‑p, Tau iso2 (human): S177‑p, Tau iso3 (human): S141‑p, Tau iso4 (human): S206‑p, Tau iso5 (human): S235‑p, Tau iso6 (human): S177‑p, Tau iso7 (human): S206‑p, Tau iso8 (human): S235‑p, Tau (mouse): S527‑p, Tau iso3 (mouse): S224‑p, Tau iso7 (mouse): S184‑p, Tau (rat): S546‑p, Tau (cow): S242‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PPP2CA (rat) decrease endogenous PPP2CA inhibitor
memantine augment treatment-induced decrease

S573-p - Tau (rat)
Modsite: NVRSKIGsTENLKHQ SwissProt Entrez-Gene
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso4 (human): S233‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PPP2CA (rat) decrease endogenous PPP2CA inhibitor
memantine augment treatment-induced decrease