Curated Information
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Home > Curated Information Page > PubMed Id: 26678338
von Eyss B, et al. (2015) A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell 28, 743-57 26678338
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T358-p - Myc (human)
Modsite: EENVkRRtHNVLERQ SwissProt Entrez-Gene
Orthologous residues
Myc (human): T358‑p, Myc iso2 (human): T373‑p, Myc (mouse): T358‑p, Myc (rat): T358‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAX (human) Disrupts transcription, inhibited co-immunoprecipitation
Disrupts transcription, induced co-immunoprecipitation
Comments:  repression of YAP/TAZ activity

S373-p - Myc (human)
Modsite: RRNELkRsFFALRDQ SwissProt Entrez-Gene
Orthologous residues
Myc (human): S373‑p, Myc iso2 (human): S388‑p, Myc (mouse): S373‑p, Myc (rat): S373‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAX (human) Disrupts transcription, induced co-immunoprecipitation
Disrupts transcription, induced co-immunoprecipitation
Comments:  repression of YAP/TAZ activity

T400-p - Myc (human)
Modsite: VVILKkAtAYILsVQ SwissProt Entrez-Gene
Orthologous residues
Myc (human): T400‑p, Myc iso2 (human): T415‑p, Myc (mouse): T400‑p, Myc (rat): T400‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Disrupts transcription, induced co-immunoprecipitation
MAX (human) Disrupts transcription, inhibited co-immunoprecipitation
Comments:  repression of YAP/TAZ activity

S94-p - YAP1 (human)
Modsite: RLRkLPDsFFkPPEP SwissProt Entrez-Gene
Orthologous residues
YAP1 (human): S94‑p, YAP1 iso2 (human): S94‑p, YAP1 iso3 (human): S94‑p, YAP1 iso5 (human): S94‑p, YAP1 iso6 (human): S94‑p, YAP1 iso7 (human): S94‑p, YAP1 iso8 (human): S94‑p, YAP1 iso9 (human): S94‑p, YAP1 (mouse): S79‑p, YAP1 (rat): S79‑p, YAP1 iso3 (rat): S79‑p, YAP1 (sheep): S9‑p, YAP1 (cow): S22‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PLD6 (human) increase siPLD6 inhibits

S127-p - YAP1 (human)
Modsite: PQHVRAHssPAsLQL SwissProt Entrez-Gene
Orthologous residues
YAP1 (human): S127‑p, YAP1 iso2 (human): S127‑p, YAP1 iso3 (human): S127‑p, YAP1 iso5 (human): S127‑p, YAP1 iso6 (human): S127‑p, YAP1 iso7 (human): S127‑p, YAP1 iso8 (human): S127‑p, YAP1 iso9 (human): S127‑p, YAP1 (mouse): S112‑p, YAP1 (rat): S112‑p, YAP1 iso3 (rat): S112‑p, YAP1 (sheep): S42‑p, YAP1 (cow): S55‑p