Curated Information
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Home > Curated Information Page > PubMed Id: 18979206
Lin G, Liu Y, MacLeod KM (2009) Regulation of muscle creatine kinase by phosphorylation in normal and diabetic hearts. Cell Mol Life Sci 66, 135-44 18979206
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S128-p - CKM (rat)
Modsite: LDPNyVLssRVRTGR SwissProt Entrez-Gene
Orthologous residues
CKM (human): S128‑p, CKM (mouse): S128‑p, CKM (rat): S128‑p, CKM (chicken): S128‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCB iso2 (human)
KINASE PKCD (rat)
Downstream Regulation
Effect of modification (function):  activity, inhibited

T638-p - PKCA (rat)
Modsite: TRGQPVLtPPDQLVI SwissProt Entrez-Gene
Orthologous residues
PKCA (human): T638‑p, PKCA (mouse): T638‑p, PKCA (rat): T638‑p, PKCA (cow): T638‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
streptozotocin no change compared to control STZ-induced diabetes

T641-p - PKCB iso2 (rat)
Modsite: tRHPPVLtPPDQEVI SwissProt Entrez-Gene
Orthologous residues
PKCB (human): , PKCB iso2 (human): T641‑p, PKCB (mouse): , PKCB iso2 (mouse): T641‑p, PKCB (rat): , PKCB iso2 (rat): T641‑p, PKCB (cow): T641‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
streptozotocin increase STZ -induced diabetes

T505-p - PKCD (rat)
Modsite: FGENRAstFCGTPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
streptozotocin no change compared to control STZ-induced diabetes

S729-p - PKCE (rat)
Modsite: QEEFKGFsYFGEDLM SwissProt Entrez-Gene
Orthologous residues
PKCE (human): S729‑p, PKCE (mouse): S729‑p, PKCE (rat): S729‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  heart
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
streptozotocin increase STZ -induced diabetes