Curated Information
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Home > Curated Information Page > PubMed Id: 18790738
Jang MS, et al. (2008) Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated factor-1. J Biol Chem 283, 32344-51 18790738
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S289-p - FAF1 (human)
Modsite: ITDVHMVsDsDGDDF SwissProt Entrez-Gene
Orthologous residues
FAF1 (human): S289‑p, FAF1 iso2 (human): , FAF1 (mouse): S288‑p, FAF1 (rat): S288‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AurA (human)
Comments:  this site is not embedded in the consensus motif of AurA substrates
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AurA (human) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme
Comments:  this site is not embedded in the consensus motif of AurA substrates
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
taxol, VX-680 decrease

S291-p - FAF1 (human)
Modsite: DVHMVsDsDGDDFED SwissProt Entrez-Gene
Orthologous residues
FAF1 (human): S291‑p, FAF1 iso2 (human): , FAF1 (mouse): S290‑p, FAF1 (rat): S290‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AurA (human)
Comments:  this site is not embedded in the consensus motif of AurA substrates
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AurA (human) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme
Comments:  this site is not embedded in the consensus motif of AurA substrates
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
taxol, VX-680 decrease