Curated Information
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Home > Curated Information Page > PubMed Id: 19029294
Zhang L, et al. (2009) Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. J Biol Chem 284, 1990-2000 19029294
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y168-p - MOR-1 (human)
Modsite: CTMSVDRyIAVCHPV SwissProt Entrez-Gene
Orthologous residues
MOR‑1 (human): Y168‑p, MOR‑1 iso5 (human): Y168‑p, MOR‑1 (mouse): Y166‑p, MOR‑1 (rat): Y166‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Comments:  Y166F mutant exhibits hyper-phosphorylation even without morphine and naloxone pretreatment

Y338-p - MOR-1 (human)
Modsite: SCLNPVLyAFLDENF SwissProt Entrez-Gene
Orthologous residues
MOR‑1 (human): Y338‑p, MOR‑1 iso5 (human): Y338‑p, MOR‑1 (mouse): Y336‑p, MOR‑1 (rat): Y336‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
morphine increase
naloxone morphine augment treatment-induced increase