Brandon NJ, Jovanovic JN, Smart TG, Moss SJ (2002) Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. J Neurosci 22, 6353-61 12151513

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S434-p - GABRB1 (rat) ▲

Modsite: GRIRRRAsQLKVKIP SwissProt Entrez-Gene Orthologous residues GABRB1 (human): S434‑p, GABRB1 (mouse): S434‑p, GABRB1 (rat): S434‑p, GABRB1 (fruit fly): V541‑p, GABRB1 iso4 (fruit fly): V541‑p, GABRB1 (cow): S434‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCA (rat) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes muscarine increase calphostin_C muscarine inhibit treatment-induced increase

S432-p - GABRB3 (rat) ▲

Modsite: KTHLRRRssQLKIKI SwissProt Entrez-Gene Orthologous residues GABRB3 (human): S432‑p, GABRB3 iso2 (human): S432‑p, GABRB3 (mouse): S432‑p, GABRB3 (rat): S432‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes muscarine increase calphostin_C muscarine inhibit treatment-induced increase

S433-p - GABRB3 (rat) ▲

Modsite: THLRRRssQLKIKIP SwissProt Entrez-Gene Orthologous residues GABRB3 (human): S433‑p, GABRB3 iso2 (human): S433‑p, GABRB3 (mouse): S433‑p, GABRB3 (rat): S433‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes muscarine increase calphostin_C muscarine inhibit treatment-induced increase