Curated Information
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Home > Curated Information Page > PubMed Id: 12065593
Huttenrauch F, et al. (2002) Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem 277, 30769-77 12065593
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S336-p - CCR5 (human)
Modsite: QEAPERAssVyTRst SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S336‑p, CCR5 (mouse): S338‑p, CCR5 (rat): S338‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil) [CCR5 (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  activity, inhibited, molecular association, regulation, receptor internalization, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ARRB1 (rat) Induces intracellular localization in vitro
ARRB2 (rat) Induces intracellular localization in vitro
Comments:  Ca(2+) response and glucosaminidase release

S337-p - CCR5 (human)
Modsite: EAPERAssVyTRstG SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S337‑p, CCR5 (mouse): S339‑p, CCR5 (rat): S339‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil) [CCR5 (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  molecular association, regulation, receptor internalization, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ARRB1 (rat) Induces intracellular localization in vitro
ARRB2 (rat) Induces intracellular localization in vitro

S342-p - CCR5 (human)
Modsite: AssVyTRstGEQEIs SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S342‑p, CCR5 (mouse): S344‑p, CCR5 (rat): S344‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil) [CCR5 (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  molecular association, regulation, receptor internalization, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ARRB1 (rat) Induces intracellular localization in vitro
ARRB2 (rat) Induces intracellular localization in vitro

S349-p - CCR5 (human)
Modsite: stGEQEIsVGL____ SwissProt Entrez-Gene
Orthologous residues
CCR5 (human): S349‑p, CCR5 (mouse): S351‑p, CCR5 (rat): S351‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil) [CCR5 (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  activity, inhibited, molecular association, regulation, receptor internalization, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ARRB2 (rat) Induces intracellular localization in vitro
ARRB1 (rat) Induces intracellular localization in vitro
Comments:  Ca(2+) response and glucosaminidase release