Procino G, et al. (2003) Ser-256 phosphorylation dynamics of Aquaporin 2 during maturation from the ER to the vesicular compartment in renal cells. FASEB J 17, 1886-8 12897058

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S256-p - AQP2 (rat) ▲

Modsite: REVRRRQsVELHsPQ SwissProt Entrez-Gene Orthologous residues AQP2 (human): S256‑p, AQP2 (mouse): S256‑p, AQP2 (rat): S256‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  RC.SV3 (renal tubule cell) Cellular systems studied:  cell lines Species studied:  rabbit Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (rat) Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes colforsin increase Downstream Regulation Effect of modification (function):  intracellular localization