Müller IM, et al. (2005) Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage. Mol Pharmacol 67, 1684-9 15703383

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T69-p - Bcl-2 (human) ▲

Modsite: SRDPVARtsPLQtPA SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): T69‑p, Bcl‑2 (mouse): T69‑p, Bcl‑2 (rat): T69‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  apoptosis, altered Comments:  The triple mutant (T69/S70/S87) was used in this study

S70-p - Bcl-2 (human) ▲

Modsite: RDPVARtsPLQtPAA SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  apoptosis, altered Comments:  The triple mutant (T69/S70/S87) was used in this study

S87-p - Bcl-2 (human) ▲

Modsite: AAAGPALsPVPPVVH SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S87‑p, Bcl‑2 (mouse): S84‑p, Bcl‑2 (rat): S84‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  apoptosis, altered Comments:  The triple mutant (T69/S70/S87) was used in this study