Jin J, et al. (2016) Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90. Mol Cell Biol 36, 1007-18 26755559

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S377-p - BAG3 (human) ▲

Modsite: PVPCPPPsPGPsAVP SwissProt Entrez-Gene Orthologous residues BAG3 (human): S377‑p, BAG3 (mouse): S382‑p, BAG3 (rat): G379‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma, leukemia, T cell leukemia Relevant cell lines - cell types - tissues:  293 (epithelial), 3T3 (fibroblast), DLD1 (intestinal), Jurkat (T lymphocyte) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes tanespimycin increase

S13-p - CDC37 (human) ▲
Modsite: VWDHIEVsDDEDETH SwissProt Entrez-Gene Orthologous residues CDC37 (human): S13‑p, CDC37 (mouse): S13‑p, CDC37 (rat): S13‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes tanespimycin decrease

Y216-p - GSK3B (human) ▲

Modsite: RGEPNVsyICsRyyR SwissProt Entrez-Gene Orthologous residues GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): Y216‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  colorectal cancer, colorectal carcinoma, leukemia, T cell leukemia Relevant cell lines - cell types - tissues:  293 (epithelial), 3T3 (fibroblast), DLD1 (intestinal), Jurkat (T lymphocyte) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  enzymatic activity, induced