Curated Information
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Home > Curated Information Page > PubMed Id: 26745677
Chabalier-Taste C, et al. (2016) Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks. Oncotarget 7, 2269-83 26745677
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1164-p - BRCA1 (human)
Modsite: GEIKEDTsFAENDIk SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1164‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S1164‑p, BRCA1 (mouse): S1127‑p, BRCA1 (rat): S1128‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) pharmacological inhibitor of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BI2536 decrease
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  DNA repair, induced
Comments:  important for foci formation following DSB

S1497-p - BRCA1 (human)
Modsite: EPGVERssPsKCPsL SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1497‑p, BRCA1 iso6 (human): S393‑p, BRCA1 iso7 (human): S1518‑p, BRCA1 (mouse): S1454‑p, BRCA1 (rat): S1455‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Disease tissue studied:  breast cancer, breast ductal carcinoma, breast cancer, triple negative
Relevant cell lines - cell types - tissues:  HCC1937 (breast cell), HeLa (cervical)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
RO-3306 decrease