Mousa SA, et al. (2016) Protein kinase C-mediated mu-opioid receptor phosphorylation and desensitization in rats, and its prevention during early diabetes. Pain 157, 910-21 26713421

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T370-p - MOR-1 (rat) ▲

Modsite: sTRVRQNtREHPsTA SwissProt Entrez-Gene Orthologous residues MOR‑1 (human): T372‑p, MOR‑1 iso5 (human): T372‑p, MOR‑1 (mouse): T370‑p, MOR‑1 (rat): T370‑p Characterization Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  neuron-dorsal root ganglia Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCA (rat) co-immunoprecipitation, phospho-antibody, pharmacological inhibitor of upstream enzyme, microscopy-colocalization Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes RAGE (rat) increase RAGE siRNA inhibits PKCA (rat) increase Associated Diseases Diseases Alterations Comments diabetes mellitus increased