Kore RA, Abraham EC (2016) Phosphorylation negatively regulates exosome mediated secretion of cryAB in glioma cells. Biochim Biophys Acta 1863, 368-77 26620801

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S19-p - CRYAB (human) ▲

Modsite: RPFFPFHsPsrLFDQ SwissProt Entrez-Gene Orthologous residues CRYAB (human): S19‑p, CRYAB (mouse): S19‑p, CRYAB (rat): S19‑p, CRYAB (rabbit): S19‑p, CRYAB (pig): S19‑p, CRYAB (cow): S19‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma Relevant cell lines - cell types - tissues:  U-118MG (glial), U373 MG (glial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  exocytosis, inhibited

S45-p - CRYAB (human) ▲

Modsite: FPTSTsLsPFYLrPP SwissProt Entrez-Gene Orthologous residues CRYAB (human): S45‑p, CRYAB (mouse): S45‑p, CRYAB (rat): S45‑p, CRYAB (rabbit): S45‑p, CRYAB (pig): S45‑p, CRYAB (cow): S45‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma Relevant cell lines - cell types - tissues:  U-118MG (glial), U373 MG (glial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  exocytosis, inhibited

S59-p - CRYAB (human) ▲

Modsite: PsFLRAPsWFDTGLS SwissProt Entrez-Gene Orthologous residues CRYAB (human): S59‑p, CRYAB (mouse): S59‑p, CRYAB (rat): S59‑p, CRYAB (rabbit): S59‑p, CRYAB (pig): S59‑p, CRYAB (cow): S59‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Disease tissue studied:  brain cancer, glioblastoma, glioblastoma multiforme, glioma Relevant cell lines - cell types - tissues:  U-118MG (glial), U373 MG (glial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  exocytosis, inhibited

T170-gl - CRYAB (human) ▲
Modsite: REEkPAVtAAPKK__ SwissProt Entrez-Gene Orthologous residues CRYAB (human): T170‑gl, CRYAB (mouse): A170‑gl, CRYAB (rat): T170‑gl, CRYAB (rabbit): T170‑gl, CRYAB (pig): T170‑gl, CRYAB (cow): T170‑gl Downstream Regulation Effect of modification (process):  exocytosis, induced