Curated Information
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Home > Curated Information Page > PubMed Id: 15743830
Arnold R, et al. (2005) Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. Mol Cell Biol 25, 2364-83 15743830
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T165-p - HPK1 (human)
Modsite: ISAQIGAtLARRLsF SwissProt Entrez-Gene
Orthologous residues
HPK1 (human): T165‑p, HPK1 (mouse): T165‑p, HPK1 (rat): T165‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE HPK1 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  transcription, altered

S171-p - HPK1 (human)
Modsite: AtLARRLsFIGtPyW SwissProt Entrez-Gene
Orthologous residues
HPK1 (human): S171‑p, HPK1 (mouse): S171‑p, HPK1 (rat): S171‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE PRKD1 (human)
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  transcription, altered

T175-p - HPK1 (human)
Modsite: RRLsFIGtPyWMAPE SwissProt Entrez-Gene
Orthologous residues
HPK1 (human): T175‑p, HPK1 (mouse): T175‑p, HPK1 (rat): T175‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Effect of modification (process):  transcription, altered