Curated Information
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Home > Curated Information Page > PubMed Id: 26675548
Abu-Odeh M, Hereema NA, Aqeilan RI (2016) WWOX modulates the ATR-mediated DNA damage checkpoint response. Oncotarget 7, 4344-55 26675548
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K274-ub - WWOX (human)
Modsite: DINDSLGkLDFSRLS SwissProt Entrez-Gene
Orthologous residues
WWOX (human): K274‑ub, WWOX (mouse): K274‑ub
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
UBIQUITIN LIGASE ITCH (human) co-immunoprecipitation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UVC increase
hydroxyurea increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein stabilization
Effect of modification (process):  cell cycle regulation, DNA repair, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ATM (human) Induces DNA repair, induced co-immunoprecipitation
Comments:  G2/M phase checkpoint activation, maintains genomic stability