Fey D, et al. (2015) Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients. Sci Signal 8, ra130 26696630

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T183-p - JNK1 (human) ▲

Modsite: AGtsFMMtPyVVtRY SwissProt Entrez-Gene Orthologous residues JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes anisomycin increase anisomycin Akt1 (human) decrease Myr-AKT1

Y185-p - JNK1 (human) ▲

Modsite: tsFMMtPyVVtRYYR SwissProt Entrez-Gene Orthologous residues JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes anisomycin increase anisomycin Akt1 (human) decrease Myr-AKT1

S80-p - MKK4 (human) ▲

Modsite: IERLRtHsIESSGkL SwissProt Entrez-Gene Orthologous residues MKK4 (human): S80‑p, MKK4 iso2 (human): S91‑p, MKK4 (mouse): S78‑p, MKK4 (rat): S78‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes Akt1 (human) increase Myr-AKT1

S257-p - MKK4 (human) ▲

Modsite: ISGQLVDsIAKtRDA SwissProt Entrez-Gene Orthologous residues MKK4 (human): S257‑p, MKK4 iso2 (human): S268‑p, MKK4 (mouse): S255‑p, MKK4 (rat): S255‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human

T261-p - MKK4 (human) ▲

Modsite: LVDsIAKtRDAGCRP SwissProt Entrez-Gene Orthologous residues MKK4 (human): T261‑p, MKK4 iso2 (human): T272‑p, MKK4 (mouse): T259‑p, MKK4 (rat): T259‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes anisomycin increase anisomycin Akt1 (human) decrease Myr-AKT1

S271-p - MKK7 (human) ▲

Modsite: IsGRLVDsKAKtRsA SwissProt Entrez-Gene Orthologous residues MKK7 (human): S271‑p, MKK7 (mouse): S287‑p, MKK7 iso2 (mouse): S271‑p, MKK7 iso6 (mouse): S287‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes anisomycin increase anisomycin Akt1 (human) decrease Myr-AKT1

T66-p - MKK7 iso2 (mouse) ▲

Modsite: ESSPQHPtPPTRPRH SwissProt Entrez-Gene Orthologous residues MKK7 (human): T66‑p, MKK7 (mouse): T82‑p, MKK7 iso2 (mouse): T66‑p, MKK7 iso6 (mouse): T82‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human

T83-p - MKK7 iso2 (mouse) ▲

Modsite: GLPSTLFtPRSMESI SwissProt Entrez-Gene Orthologous residues MKK7 (human): T83‑p, MKK7 (mouse): T99‑p, MKK7 iso2 (mouse): T83‑p, MKK7 iso6 (mouse): T99‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  neuroblastoma Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest) Cellular systems studied:  cell lines Species studied:  human