Curated Information
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Home > Curated Information Page > PubMed Id: 26696630
Fey D, et al. (2015) Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients. Sci Signal 8, ra130 26696630
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T183-p - JNK1 (human)
Modsite: AGtsFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
anisomycin Akt1 (human) decrease Myr-AKT1

Y185-p - JNK1 (human)
Modsite: tsFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
anisomycin Akt1 (human) decrease Myr-AKT1

S80-p - MKK4 (human)
Modsite: IERLRtHsIESSGkL SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): S80‑p, MKK4 iso2 (human): S91‑p, MKK4 (mouse): S78‑p, MKK4 (rat): S78‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Akt1 (human) increase Myr-AKT1

S257-p - MKK4 (human)
Modsite: ISGQLVDsIAKtRDA SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): S257‑p, MKK4 iso2 (human): S268‑p, MKK4 (mouse): S255‑p, MKK4 (rat): S255‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human

T261-p - MKK4 (human)
Modsite: LVDsIAKtRDAGCRP SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): T261‑p, MKK4 iso2 (human): T272‑p, MKK4 (mouse): T259‑p, MKK4 (rat): T259‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
anisomycin Akt1 (human) decrease Myr-AKT1

S271-p - MKK7 (human)
Modsite: IsGRLVDsKAKtRsA SwissProt Entrez-Gene
Orthologous residues
MKK7 (human): S271‑p, MKK7 (mouse): S287‑p, MKK7 iso2 (mouse): S271‑p, MKK7 iso6 (mouse): S287‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
anisomycin Akt1 (human) decrease Myr-AKT1

T66-p - MKK7 iso2 (mouse)
Modsite: ESSPQHPtPPTRPRH SwissProt Entrez-Gene
Orthologous residues
MKK7 (human): T66‑p, MKK7 (mouse): T82‑p, MKK7 iso2 (mouse): T66‑p, MKK7 iso6 (mouse): T82‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human

T83-p - MKK7 iso2 (mouse)
Modsite: GLPSTLFtPRSMESI SwissProt Entrez-Gene
Orthologous residues
MKK7 (human): T83‑p, MKK7 (mouse): T99‑p, MKK7 iso2 (mouse): T83‑p, MKK7 iso6 (mouse): T99‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  human