Curated Information
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Home > Curated Information Page > PubMed Id: 26692175
Li S, et al. (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nat Immunol 17, 241-9 26692175
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S97-p - IRF3 (mouse)
Modsite: LRLAADNsKDPYDPH SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S97‑p, IRF3 (mouse): S97‑p, IRF3 (rat): S97‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PTEN (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTEN (mouse) co-immunoprecipitation
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  dephosphorylated S97 promoted nuclear import

S332-p - IRF3 (mouse)
Modsite: FMEGSGHsPRYTLWF SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S339‑p, IRF3 (mouse): S332‑p, IRF3 (rat): S334‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse

S388-p - IRF3 (mouse)
Modsite: KTVDLHIsNSQPISL SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S396‑p, IRF3 (mouse): S388‑p, IRF3 (rat): S390‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  293 (epithelial), MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human, mouse