Curated Information
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Home > Curated Information Page > PubMed Id: 26546672
Gong J, Holewinski RJ, Van Eyk JE, Steinberg SF (2016) A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ. Biochem J 473, 311-20 26546672
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T37-p - PKCD (rat)
Modsite: VKMKEALttDRGKTL SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S37‑p, PKCD iso2 (human): S37‑p, PKCD (mouse): S37‑p, PKCD iso2 (mouse): S37‑p, PKCD (rat): T37‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T38-p - PKCD (rat)
Modsite: KMKEALttDRGKTLV SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T38‑p, PKCD iso2 (human): T38‑p, PKCD (mouse): T38‑p, PKCD iso2 (mouse): T38‑p, PKCD (rat): T38‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T50-p - PKCD (rat)
Modsite: TLVQKKPtMYPEWKS SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T50‑p, PKCD iso2 (human): T50‑p, PKCD (mouse): T50‑p, PKCD iso2 (mouse): T50‑p, PKCD (rat): T50‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S130-p - PKCD (rat)
Modsite: EDGDCKQsMRSEEEA SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S130‑p, PKCD iso2 (human): S130‑p, PKCD (mouse): S130‑p, PKCD iso2 (mouse): S130‑p, PKCD (rat): S130‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial), myocyte-heart
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  human, rat
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, phosphorylation
Comments:  downregulates phosphorylation of S357

T141-p - PKCD (rat)
Modsite: EEEAMFPtMNRRGAI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T141‑p, PKCD iso2 (human): T141‑p, PKCD (mouse): T141‑p, PKCD iso2 (mouse): T141‑p, PKCD (rat): T141‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site
Relevant cell lines - cell types - tissues:  293 (epithelial), myocyte-heart
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  human, rat
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, phosphorylation
Comments:  downregulates phosphorylation of S357

T164-p - PKCD (rat)
Modsite: KNHEFIAtFFGQPTF SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T164‑p, PKCD iso2 (human): T164‑p, PKCD (mouse): T164‑p, PKCD iso2 (mouse): T164‑p, PKCD (rat): T164‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T211-p - PKCD (rat)
Modsite: IIGRCTGtAtNsRDt SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T211‑p, PKCD iso2 (human): T211‑p, PKCD (mouse): T211‑p, PKCD iso2 (mouse): T211‑p, PKCD (rat): T211‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T213-p - PKCD (rat)
Modsite: GRCTGtAtNsRDtIF SwissProt Entrez-Gene
Orthologous residues
PKCD (human): A213‑p, PKCD iso2 (human): A213‑p, PKCD (mouse): T213‑p, PKCD iso2 (mouse): T213‑p, PKCD (rat): T213‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S215-p - PKCD (rat)
Modsite: CTGtAtNsRDtIFQK SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S215‑p, PKCD iso2 (human): S215‑p, PKCD (mouse): S215‑p, PKCD iso2 (mouse): S215‑p, PKCD (rat): S215‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T218-p - PKCD (rat)
Modsite: tAtNsRDtIFQKERF SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T218‑p, PKCD iso2 (human): T218‑p, PKCD (mouse): T218‑p, PKCD iso2 (mouse): T218‑p, PKCD (rat): T218‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T295-p - PKCD (rat)
Modsite: AEALNQVtQKAsRKP SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T295‑p, PKCD iso2 (human): T295‑p, PKCD (mouse): T295‑p, PKCD iso2 (mouse): T295‑p, PKCD (rat): T295‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S299-p - PKCD (rat)
Modsite: NQVtQKAsRKPETPE SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S299‑p, PKCD iso2 (human): S299‑p, PKCD (mouse): S299‑p, PKCD iso2 (mouse): S299‑p, PKCD (rat): S299‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S357-p - PKCD (rat)
Modsite: QKVLGKGsFGKVLLA SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S359‑p, PKCD iso2 (human): S390‑p, PKCD (mouse): S357‑p, PKCD iso2 (mouse): S383‑p, PKCD (rat): S357‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol_ester increase
GF109203X phorbol_ester inhibit treatment-induced increase

S504-p - PKCD (rat)
Modsite: IFGENRAstFCGTPD SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S506‑p, PKCD iso2 (human): S537‑p, PKCD (mouse): S504‑p, PKCD iso2 (mouse): S530‑p, PKCD (rat): S504‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T505-p - PKCD (rat)
Modsite: FGENRAstFCGTPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S643-p - PKCD (rat)
Modsite: LNEKPQLsFsDKNLI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S645‑p, PKCD iso2 (human): S676‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S645-p - PKCD (rat)
Modsite: EKPQLsFsDKNLIDS SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S647‑p, PKCD iso2 (human): S678‑p, PKCD (mouse): S645‑p, PKCD iso2 (mouse): S671‑p, PKCD (rat): S645‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

T656-p - PKCD (rat)
Modsite: LIDSMDQtAFKGFsF SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S658‑p, PKCD iso2 (human): S689‑p, PKCD (mouse): E656‑p, PKCD iso2 (mouse): E682‑p, PKCD (rat): T656‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat

S662-p - PKCD (rat)
Modsite: QtAFKGFsFVNPKYE SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S664‑p, PKCD iso2 (human): S695‑p, PKCD (mouse): S662‑p, PKCD iso2 (mouse): S688‑p, PKCD (rat): S662‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, phospho-antibody
Relevant cell lines - cell types - tissues:  myocyte-heart
Cellular systems studied:  primary cultured cells
Species studied:  rat