Curated Information
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Home > Curated Information Page > PubMed Id: 23420876
Matin RN, et al. (2013) p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. J Exp Med 210, 581-603 23420876
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S15-p - p53 (human)
Modsite: PsVEPPLsQEtFsDL SwissProt Entrez-Gene
Orthologous residues
p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): , p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
taxol no change compared to control

S46-p - p53 (human)
Modsite: AMDDLMLsPDDIEQW SwissProt Entrez-Gene
Orthologous residues
p53 (human): S46‑p, p53 iso2 (human): S46‑p, p53 iso4 (human): S7‑p, p53 (mouse): , p53 iso2 (mouse): , p53 (rat): , p53 (rabbit): S45‑p, p53 (green monkey): S46‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
taxol increase sight increase

S160-p - p63 (human)
Modsite: SSTFDALsPsPAIPS SwissProt Entrez-Gene
Orthologous residues
p63 (human): S160‑p, p63 iso2 (human): S66‑p, p63 (mouse): S160‑p, p63 (rat): S160‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
taxol increase
Downstream Regulation
Effect of modification (function):  intracellular localization, protein stabilization
Comments:  nuclear stabilization of phosphorylated p63 in response to paclitaxel, partially relocates to the mitochondria

S162-p - p63 (human)
Modsite: TFDALsPsPAIPSNT SwissProt Entrez-Gene
Orthologous residues
p63 (human): S162‑p, p63 iso2 (human): S68‑p, p63 (mouse): S162‑p, p63 (rat): S162‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
taxol increase
Downstream Regulation
Effect of modification (function):  intracellular localization, protein stabilization
Comments:  nuclear stabilization of phosphorylated p63 in response to paclitaxel, partially relocates to the mitochondria