Zhang Z, et al. (2015) DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med 212, 2165-82 26552706

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y319-p - DNAM-1 (mouse) ▲

Modsite: DDEKEDIyVNYPTFs SwissProt Entrez-Gene Orthologous residues DNAM‑1 (human): Y322‑p, DNAM‑1 (mouse): Y319‑p, DNAM‑1 (rat): Y332‑p Characterization Methods used to characterize site in vivo:  flow cytometry, immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  lymphocyte-spleen, YTS Cellular systems studied:  cell lines, primary cells Species studied:  human, mouse Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cytoskeletal reorganization Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays GRB2 (mouse) SH2 Induces molecular association, regulation co-immunoprecipitation VAV1 (mouse) Induces co-immunoprecipitation PIK3R1 (mouse) Induces co-immunoprecipitation Comments:  DNAM-1 dependent natural cytotoxicity

S326-p - DNAM-1 (mouse) ▲

Modsite: yVNYPTFsRRPKPRL SwissProt Entrez-Gene Orthologous residues DNAM‑1 (human): S329‑p, DNAM‑1 (mouse): S326‑p, DNAM‑1 (rat): S339‑p Characterization Methods used to characterize site in vivo:  flow cytometry, immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  lymphocyte-spleen, YTS Cellular systems studied:  cell lines, primary cells Species studied:  human, mouse