Curated Information
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Home > Curated Information Page > PubMed Id: 26436589
Nakakido M, et al. (2015) PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget 6, 30957-67 26436589
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T145-p - p21Cip1 (human)
Modsite: QGRkRRQtsMTDFyH SwissProt Entrez-Gene
Orthologous residues
p21Cip1 (human): T145‑p, p21Cip1 (mouse): T140‑p, p21Cip1 (dog): T113‑p
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  R156 methylation enhances phosphorylation of T145

R156-m2 - p21Cip1 (human)
Modsite: DFyHskRrLIFSkRk SwissProt Entrez-Gene
Orthologous residues
p21Cip1 (human): R156‑m2, p21Cip1 (mouse): R151‑m2, p21Cip1 (dog): R124‑m2
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE PRMT6 (human) transfection of wild-type enzyme, co-immunoprecipitation, phosphopeptide analysis, modification-specific antibody
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  cytoplasmic localization of p21