Curated Information
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Home > Curated Information Page > PubMed Id: 26471730
Lai YC, et al. (2015) Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1. EMBO J 34, 2840-61 26471730
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S65-p - PARK2 (human)
Modsite: NCDLDQQsIVHIVQR SwissProt Entrez-Gene
Orthologous residues
PARK2 (human): S65‑p, PARK2 (mouse): S65‑p, PARK2 (rat): S65‑p

S111-p - RAB13 (human)
Modsite: kSIkENAsAGVERLL SwissProt Entrez-Gene
Orthologous residues
RAB13 (human): S111‑p, RAB13 (mouse): S111‑p, RAB13 (rat): S111‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCCP increase
PINK1 (human) increase PINK1 -/- inhibits

S111-p - RAB8A (human)
Modsite: RNIEEHAsADVEkMI SwissProt Entrez-Gene
Orthologous residues
RAB8A (human): S111‑p, RAB8A (mouse): S111‑p, RAB8A (rat): S111‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCCP increase
PINK1 (human) increase PINK1 -/- inhibits
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAB3IP (human) Disrupts co-immunoprecipitation

S111-p - RAB8B (human)
Modsite: RNIEEHAssDVERMI SwissProt Entrez-Gene
Orthologous residues
RAB8B (human): S111‑p, RAB8B (mouse): S111‑p, RAB8B (rat): S111‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCCP increase
PINK1 (human) increase PINK1 -/- inhibits