Curated Information
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Home > Curated Information Page > PubMed Id: 26307683
Zhou N, et al. (2015) Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence. Oncotarget 6, 30745-30761 26307683
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S10-p - p27Kip1 (human)
Modsite: NVRVSNGsPsLErMD SwissProt Entrez-Gene
Orthologous residues
p27Kip1 (human): S10‑p, p27Kip1 (mouse): S10‑p, p27Kip1 (rat): S10‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  hTERT-RPE1 (epithelial), keratinocyte-skin
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase HPV E7 expression
DYRK1B (human) increase siRNA inhibits
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  cell cycle regulation
Comments:  S-phase entry in E7 expressing cells

T198-p - p27Kip1 (human)
Modsite: PGLRRRQt_______ SwissProt Entrez-Gene
Orthologous residues
p27Kip1 (human): T198‑p, p27Kip1 (mouse): T197‑p, p27Kip1 (rat): T197‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  hTERT-RPE1 (epithelial), keratinocyte-skin
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase HPV E7 expression
DYRK1B (human) increase siRNA inhibits
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  cell cycle regulation
Comments:  S-phase entry in E7 expressing cells