Curated Information
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Home > Curated Information Page > PubMed Id: 26378614
Du TT, et al. (2015) GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A. Autophagy 11, 1803-20 26378614
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y307-p - PPP2CA (human)
Modsite: VTRRtPDyFl_____ SwissProt Entrez-Gene
Orthologous residues
PPP2CA (human): Y307‑p, PPP2CA iso2 (human): Y253‑p, PPP2CA (mouse): Y307‑p, PPP2CA (rat): Y307‑p, PPP2CA (pig): Y307‑p, PPP2CA (cow): Y307‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  'neuron, cortical', SKNSH (neural crest)
Cellular systems studied:  cell lines
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GBA (human) decrease shGBA increases
C2-ceramide decrease
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Effect of modification (process):  autophagy, inhibited, translation, induced
Comments:  may contribute to SNCA accumulation

Y307-p - PPP2CA (rat)
Modsite: VTRRTPDyFl_____ SwissProt Entrez-Gene
Orthologous residues
PPP2CA (human): Y307‑p, PPP2CA iso2 (human): Y253‑p, PPP2CA (mouse): Y307‑p, PPP2CA (rat): Y307‑p, PPP2CA (pig): Y307‑p, PPP2CA (cow): Y307‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  'neuron, cortical', SKNSH (neural crest)
Cellular systems studied:  cell lines
Species studied:  human, rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GBA (human) decrease shGBA increases
C2-ceramide decrease
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Effect of modification (process):  autophagy, inhibited, translation, induced
Comments:  may contribute to SNCA accumulation