Curated Information
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Home > Curated Information Page > PubMed Id: 26320175
Beckta JM, et al. (2015) Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget 6, 27674-87 26320175
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S1387-p - BRCA1 (human)
Modsite: EDCSGLSsQSDILTT SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1387‑p, BRCA1 iso6 (human): S284‑p, BRCA1 iso7 (human): S1387‑p, BRCA1 (mouse): S1343‑p, BRCA1 (rat): S1344‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  breast cancer, breast ductal carcinoma, breast cancer, triple negative
Relevant cell lines - cell types - tissues:  HCC1937 (breast cell)
Cellular systems studied:  cell lines

S1423-p - BRCA1 (human)
Modsite: AVLEQHGsQPSNSYP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1423‑p, BRCA1 iso6 (human): S320‑p, BRCA1 iso7 (human): S1423‑p, BRCA1 (mouse): N1379‑p, BRCA1 (rat): S1380‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  breast cancer, breast ductal carcinoma, breast cancer, triple negative
Relevant cell lines - cell types - tissues:  HCC1937 (breast cell)
Cellular systems studied:  cell lines

S1457-p - BRCA1 (human)
Modsite: SEKAVLTsQKsSEYP SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1457‑p, BRCA1 iso6 (human): S353‑p, BRCA1 iso7 (human): S1478‑p, BRCA1 (mouse): S1413‑p, BRCA1 (rat): S1414‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  breast cancer, breast ductal carcinoma, breast cancer, triple negative
Relevant cell lines - cell types - tissues:  HCC1937 (breast cell)
Cellular systems studied:  cell lines

S1524-p - BRCA1 (human)
Modsite: LQNRNYPsQEELIKV SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S1524‑p, BRCA1 iso6 (human): S420‑p, BRCA1 iso7 (human): S1545‑p, BRCA1 (mouse): S1481‑p, BRCA1 (rat): S1482‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  breast cancer, breast ductal carcinoma, breast cancer, triple negative
Relevant cell lines - cell types - tissues:  HCC1937 (breast cell)
Cellular systems studied:  cell lines