Iwamoto N, Abe-Dohmae S, Lu R, Yokoyama S (2008) Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol 28, 2282-7 18845787

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S258-p - AP-2 alpha (human) ▲

Modsite: GVLRRAKsKNGGRSL SwissProt Entrez-Gene Orthologous residues AP‑2 alpha (human): S258‑p, AP‑2 alpha iso2 (human): S252‑p, AP‑2 alpha (mouse): S258‑p, AP‑2 alpha (rat): S258‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Disease tissue studied:  leukemia, acute myelogenous leukemia, liver cancer Relevant cell lines - cell types - tissues:  293 (epithelial), HepG2 (hepatic), THP1 (myeloid) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Induces co-immunoprecipitation, EMSA

S326-p - AP-2 alpha (human) ▲
Modsite: EFLNRQHsDPNEQVT SwissProt Entrez-Gene Orthologous residues AP‑2 alpha (human): S326‑p, AP‑2 alpha iso2 (human): S320‑p, AP‑2 alpha (mouse): S326‑p, AP‑2 alpha (rat): S326‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE PRKD1 (human)