Curated Information
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Home > Curated Information Page > PubMed Id: 11035798
Chao C, et al. (2000) Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage. Proc Natl Acad Sci U S A 97, 11936-41 11035798
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S18-p - p53 (mouse)
Modsite: IsLELPLsQEtFsGL SwissProt Entrez-Gene
Orthologous residues
p53 (human): S15‑p, p53 iso2 (human): S15‑p, p53 iso4 (human): , p53 (mouse): S18‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (green monkey): S15‑p
Characterization
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  ES (stem)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing_radiation increase
UV increase

K317-ac - p53 (mouse)
Modsite: sAsPPQkkkPLDGEy SwissProt Entrez-Gene
Orthologous residues
p53 (human): K320‑ac, p53 iso2 (human): K320‑ac, p53 iso4 (human): K281‑ac, p53 (mouse): K317‑ac, p53 iso2 (mouse): K317‑ac, p53 (rat): K318‑ac, p53 (rabbit): K318‑ac, p53 (green monkey): K320‑ac
Characterization
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  ES (stem)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase

K379-ac - p53 (mouse)
Modsite: QsTsRHkkTMVkkVG SwissProt Entrez-Gene
Orthologous residues
p53 (human): K382‑ac, p53 iso2 (human): , p53 iso4 (human): K343‑ac, p53 (mouse): K379‑ac, p53 iso2 (mouse): , p53 (rat): K380‑ac, p53 (rabbit): K380‑ac, p53 (green monkey): K382‑ac
Characterization
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  ES (stem)
Cellular systems studied:  cell lines
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase