Curated Information
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Home > Curated Information Page > PubMed Id: 26184911
Yoon S, Bogdanov K, Kovalenko A, Wallach D (2016) Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it. Cell Death Differ 23, 253-60 26184911
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T357-p - MLKL (human)
Modsite: FELRkTQtsMSLGTt SwissProt Entrez-Gene
Orthologous residues
MLKL (human): T357‑p, MLKL (mouse): N344‑p, MLKL (rat): T344‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma
Relevant cell lines - cell types - tissues:  HT-29 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  intracellular localization, protein conformation
Comments:  nuclear translocation of MLKL , RIPK1, and RIPK3 then cell membrane and necroptotic death

S358-p - MLKL (human)
Modsite: ELRkTQtsMSLGTtR SwissProt Entrez-Gene
Orthologous residues
MLKL (human): S358‑p, MLKL (mouse): S345‑p, MLKL (rat): S345‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma
Relevant cell lines - cell types - tissues:  HT-29 (intestinal)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (function):  intracellular localization, protein conformation
Comments:  nuclear translocation of MLKL , RIPK1, and RIPK3 then cell membrane and necroptotic death