Fairlie WD, De Souza D, Nicola NA, Baca M (2003) Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2. Biochem J 372, 495-502 12593670

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Y757-p - gp130 (mouse) ▲

Modsite: STASTVQySTVVHSG SwissProt Entrez-Gene Orthologous residues gp130 (human): Y759‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): Y698‑p, gp130 (mouse): Y757‑p, gp130 (rat): Y758‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  molecular association, regulation, phosphorylation Effect of modification (process):  transcription, altered Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays SOCS3 (mouse) Induces pull-down assay SHP-2 (human) Induces pull-down assay Comments:  SHP-2 phosphorylation