Kamimura D, et al. (2002) Tyrosine 759 of the cytokine receptor gp130 is involved in Listeria monocytogenes susceptibility. Genes Immun 3, 136-43 12070777

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Y757-p - gp130 (mouse) ▲

Modsite: STASTVQySTVVHSG SwissProt Entrez-Gene Orthologous residues gp130 (human): Y759‑p, gp130 iso2 (human): ‑, gp130 iso3 (human): Y698‑p, gp130 (mouse): Y757‑p, gp130 (rat): Y758‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  splenocyte Cellular systems studied:  primary cells Species studied:  mouse Downstream Regulation Effect of modification (function):  activity, induced Comments:  protection from bacterial infection, promotes increases in IFN-gamma levels