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Home > Curated Information Page > PubMed Id: 15928203
Khaled AR, et al. (2005) Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol 169, 755-63 15928203
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S75-p - CDC25A (mouse)
Modsite: SSLQRMGsSESTDSG SwissProt Entrez-Gene
Orthologous residues
CDC25A (human): S76‑p, CDC25A iso2 (human): S76‑p, CDC25A (mouse): S75‑p, CDC25A (rat): S76‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  apoptosis, altered, cell cycle regulation

S123-p - CDC25A (mouse)
Modsite: PALKRSHsDSLDHDT SwissProt Entrez-Gene
Orthologous residues
CDC25A (human): S124‑p, CDC25A iso2 (human): S124‑p, CDC25A (mouse): S123‑p, CDC25A (rat): S124‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  protein degradation
Effect of modification (process):  apoptosis, altered, cell cycle regulation

Y15-p - CDK1 (mouse)
Modsite: EKIGEGtyGVVyKGR SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3_withdrawal decrease

T161-p - CDK1 (mouse)
Modsite: GIPIRVytHEVVTLW SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): T161‑p, CDK1 iso2 (human): , CDK1 (mouse): T161‑p, CDK1 (rat): T161‑p, CDK1 (chicken): T161‑p, CDK1 (fruit fly): T161‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3_withdrawal decrease

Y15-p - CDK2 (mouse)
Modsite: EKIGEGtyGVVyKAK SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): Y15‑p, CDK2 iso2 (human): Y15‑p, CDK2 (mouse): Y15‑p, CDK2 (rat): Y15‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3_withdrawal decrease

T160-p - CDK2 (mouse)
Modsite: GVPVRtYtHEVVTLW SwissProt Entrez-Gene
Orthologous residues
CDK2 (human): T160‑p, CDK2 iso2 (human): T160‑p, CDK2 (mouse): T160‑p, CDK2 (rat): T160‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3_withdrawal decrease

S773-p - Rb (mouse)
Modsite: STRPPtLsPIPHIPR SwissProt Entrez-Gene
Orthologous residues
Rb (human): S780‑p, Rb (mouse): S773‑p, Rb (rat): S772‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'B lymphocyte, precursor', thymocyte
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PD169316 increase
IL-3_withdrawal decrease
PD169316 IL-3_withdrawal inhibit treatment-induced decrease