Curated Information
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Home > Curated Information Page > PubMed Id: 14581488
Watanabe H, et al. (2004) Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts. J Biol Chem 279, 1676-83 14581488
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T638-p - PKCA (human)
Modsite: TRGQPVLtPPDQLVI SwissProt Entrez-Gene
Orthologous residues
PKCA (human): T638‑p, PKCA (mouse): T638‑p, PKCA (rat): T638‑p, PKCA (cow): T638‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  fibroblast-skin
Cellular systems studied:  primary cultured cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MIF increase
PP2 MIF inhibit treatment-induced increase
genistein MIF inhibit treatment-induced increase
herbimycin_A MIF inhibit treatment-induced increase

T641-p - PKCB iso2 (human)
Modsite: tRHPPVLtPPDQEVI SwissProt Entrez-Gene
Orthologous residues
PKCB (human): , PKCB iso2 (human): T641‑p, PKCB (mouse): , PKCB iso2 (mouse): T641‑p, PKCB (rat): , PKCB iso2 (rat): T641‑p, PKCB (cow): T641‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  fibroblast-skin
Cellular systems studied:  primary cultured cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MIF increase
PP2 MIF inhibit treatment-induced increase
genistein MIF inhibit treatment-induced increase
herbimycin_A MIF inhibit treatment-induced increase

T507-p - PKCD (human)
Modsite: FGEsRAstFCGtPDy SwissProt Entrez-Gene
Orthologous residues
PKCD (human): T507‑p, PKCD iso2 (human): T538‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  fibroblast-skin
Cellular systems studied:  primary cultured cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MIF increase

S645-p - PKCD (human)
Modsite: LNEkARLsysDKNLI SwissProt Entrez-Gene
Orthologous residues
PKCD (human): S645‑p, PKCD iso2 (human): S676‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  fibroblast-skin
Cellular systems studied:  primary cultured cells
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
MIF increase