Curated Information
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Home > Curated Information Page > PubMed Id: 14976148
Zahradka P, Litchie B, Storie B, Helwer G (2004) Transactivation of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to phosphatidylinositol 3-kinase. Endocrinology 145, 2978-87 14976148
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T202-p - ERK1 (human)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery'
Cellular systems studied:  primary cultured cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin increase
PP1, angiotensin inhibit treatment-induced increase

Y204-p - ERK1 (human)
Modsite: HtGFLtEyVAtRWyr SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery'
Cellular systems studied:  primary cultured cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin increase
PP1, angiotensin inhibit treatment-induced increase

T412-p - p70S6K (human)
Modsite: NQVFLGFtyVAPsVL SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery'
Cellular systems studied:  primary cultured cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin increase
PP1, angiotensin inhibit treatment-induced increase
LY294002, angiotensin inhibit treatment-induced increase
AG1024, angiotensin inhibit treatment-induced increase

S1069-p - EGFR (pig)
Modsite: DSFLQRYsSDPTGAL SwissProt Entrez-Gene
Orthologous residues
EGFR (human): S1070‑p, EGFR iso2 (human): , EGFR iso5 (human): S1070‑p, EGFR (mouse): S1070‑p, EGFR (rat): S1069‑p, EGFR (pig): S1069‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery'
Cellular systems studied:  primary cultured cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF, AG1478 inhibit treatment-induced increase
EGF increase

Y1161-p - IGF1R (pig)
Modsite: FGMTRDIyETDYYRK SwissProt Entrez-Gene
Orthologous residues
IGF1R (human): Y1161‑p, IGF1R (mouse): Y1163‑p, IGF1R (rat): Y1162‑p, IGF1R (pig): Y1161‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Relevant cell lines - cell types - tissues:  'muscle, smooth'-'heart, artery'
Cellular systems studied:  primary cultured cells
Species studied:  pig
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
angiotensin increase
IGF-1 increase
PP1, angiotensin inhibit treatment-induced increase
losartan, angiotensin inhibit treatment-induced increase
AG1478, IGF-1 inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  activity, induced