Thériault JR, et al. (2004) Essential role of the NH2-terminal WD/EPF motif in the phosphorylation-activated protective function of mammalian Hsp27. J Biol Chem 279, 23463-71 15033973

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S15-p - HSP27 (hamster) ▲

Modsite: FSLLRSPsWEPFRDW SwissProt Orthologous residues HSP27 (human): S15‑p, HSP27 (mouse): S15‑p, HSP27 (rat): S15‑p, HSP27 (pig): S15‑p, HSP27 (hamster): S15‑p, HSP27 (chicken): S15‑p, HSP27 (dog): S15‑p, HSP27 (cow): S15‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  activity, induced Comments:  Activation of Hsp27 thermoprotective activity

S90-p - HSP27 (hamster) ▲

Modsite: RALNRQLsSGVSEIR SwissProt Orthologous residues HSP27 (human): S82‑p, HSP27 (mouse): S86‑p, HSP27 (rat): S86‑p, HSP27 (pig): S84‑p, HSP27 (hamster): S90‑p, HSP27 (chicken): S80‑p, HSP27 (dog): S86‑p, HSP27 (cow): S78‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] Cellular systems studied:  cell lines Species studied:  mouse Downstream Regulation Effect of modification (function):  activity, induced Comments:  Activation of Hsp27 thermoprotective activity