Thomas A, Giesler T, White E (2000) p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene 19, 5259-69 11077443

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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T56-p - Bcl-2 (human) ▲

Modsite: FSSQPGHtPHPAASR SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): T56‑p, Bcl‑2 (mouse): N56‑p, Bcl‑2 (rat): N56‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  epithelial-'kidney, tubule' Cellular systems studied:  primary cells Species studied:  rat Downstream Regulation Effect of modification (process):  apoptosis, altered

S70-p - Bcl-2 (human) ▲

Modsite: RDPVARtsPLQtPAA SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  epithelial-'kidney, tubule' Cellular systems studied:  primary cells Species studied:  rat Downstream Regulation Effect of modification (process):  apoptosis, altered

T74-p - Bcl-2 (human) ▲

Modsite: ARtsPLQtPAAPGAA SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): T74‑p, Bcl‑2 (mouse): P74‑p, Bcl‑2 (rat): P74‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  epithelial-'kidney, tubule' Cellular systems studied:  primary cells Species studied:  rat Downstream Regulation Effect of modification (process):  apoptosis, altered

S87-p - Bcl-2 (human) ▲

Modsite: AAAGPALsPVPPVVH SwissProt Entrez-Gene Orthologous residues Bcl‑2 (human): S87‑p, Bcl‑2 (mouse): S84‑p, Bcl‑2 (rat): S84‑p Characterization Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site Relevant cell lines - cell types - tissues:  epithelial-'kidney, tubule' Cellular systems studied:  primary cells Species studied:  rat Downstream Regulation Effect of modification (process):  apoptosis, altered