Curated Information
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Home > Curated Information Page > PubMed Id: 15456867
Usui I, et al. (2004) beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Mol Cell Biol 24, 8929-37 15456867
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S412-p - ARRB1 (human)
Modsite: EEEDGtGsPQLNNR_ SwissProt Entrez-Gene
Orthologous residues
ARRB1 (human): S412‑p, ARRB1 iso2 (human): S404‑p, ARRB1 (mouse): S412‑p, ARRB1 (rat): S412‑p, ARRB1 (cow): S412‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  activity, induced
Comments:  degradation of IRS1/2

T308-p - Akt1 (rat)
Modsite: KDGATMKtFCGTPEy SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T308‑p, Akt1 iso2 (human): T246‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  Rat1 (fibroblast) [INSR (human)]
Cellular systems studied:  cell lines
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase
insulin ARRB1 (human) inhibit treatment-induced increase
insulin insulin inhibit treatment-induced increase restimulation
insulin ARRB1 (human) inhibit treatment-induced decrease after insulin restimulation
wortmannin ARRB1 (human) inhibit treatment-induced increase after insulin restimulation/ARRB1