Sengupta T, Chen K, Milot E, Bieker JJ (2008) Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus. Mol Cell Biol 28, 6160-70 18710946

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

K288-ac - KLF1 (human) ▲

Modsite: CAHPGCGkSYTKSSH SwissProt Entrez-Gene Orthologous residues KLF1 (human): K288‑ac, KLF1 (mouse): K284‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  18SCF (hepatocyte), HEK293T (epithelial), MEL (erythroid) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  acetylation, molecular association, regulation Effect of modification (process):  chromatin organization, altered, transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays Induces Comments:  induces H3 acetylation