Curated Information
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Home > Curated Information Page > PubMed Id: 28784767
Despres C, et al. (2017) Identification of the Tau phosphorylation pattern that drives its aggregation. Proc Natl Acad Sci U S A 114, 9080-9085 28784767
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S513-p - Tau (rat)
Modsite: SGyssPGsPGtPGsR SwissProt Entrez-Gene
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso4 (human): S173‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Comments:  aggregation

T516-p - Tau (rat)
Modsite: ssPGsPGtPGsRSRt SwissProt Entrez-Gene
Orthologous residues
Tau (human): T522‑p, Tau iso2 (human): T147‑p, Tau iso3 (human): T111‑p, Tau iso4 (human): T176‑p, Tau iso5 (human): T205‑p, Tau iso6 (human): T147‑p, Tau iso7 (human): T176‑p, Tau iso8 (human): T205‑p, Tau (mouse): T497‑p, Tau iso3 (mouse): T194‑p, Tau iso7 (mouse): T154‑p, Tau (rat): T516‑p, Tau (cow): T212‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Comments:  aggregation

S519-p - Tau (rat)
Modsite: GsPGtPGsRSRtPsL SwissProt Entrez-Gene
Orthologous residues
Tau (human): S525‑p, Tau iso2 (human): S150‑p, Tau iso3 (human): S114‑p, Tau iso4 (human): S179‑p, Tau iso5 (human): S208‑p, Tau iso6 (human): S150‑p, Tau iso7 (human): S179‑p, Tau iso8 (human): S208‑p, Tau (mouse): S500‑p, Tau iso3 (mouse): S197‑p, Tau iso7 (mouse): S157‑p, Tau (rat): S519‑p, Tau (cow): S215‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Comments:  aggregation

S573-p - Tau (rat)
Modsite: NVRSKIGsTENLKHQ SwissProt Entrez-Gene
Orthologous residues
Tau (human): S579‑p, Tau iso2 (human): S204‑p, Tau iso3 (human): S168‑p, Tau iso4 (human): S233‑p, Tau iso5 (human): S262‑p, Tau iso6 (human): S204‑p, Tau iso7 (human): S233‑p, Tau iso8 (human): S262‑p, Tau (mouse): S554‑p, Tau iso3 (mouse): S251‑p, Tau iso7 (mouse): S211‑p, Tau (rat): S573‑p, Tau (cow): S269‑p
Characterization
Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  E.coli (bacterial)
Cellular systems studied:  cell lines
Species studied:  bacteria
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Comments:  inhibits aggregation