Curated Information
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Home > Curated Information Page > PubMed Id: 28758999
Caccamo A, et al. (2017) Necroptosis activation in Alzheimer's disease. Nat Neurosci 20, 1236-1246 28758999
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T357-p - MLKL (human)
Modsite: FELRkTQtsMSLGTt SwissProt Entrez-Gene
Orthologous residues
MLKL (human): T357‑p, MLKL (mouse): N344‑p, MLKL (rat): T344‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human
Comments:  double stained sections from AD patients
Downstream Regulation
Effect of modification (function):  intracellular localization, protein conformation
Comments:  colocalization of RIPK1, pMLK1, and tau phosphorylated at S202, necroptosis
Associated Diseases
Diseases Alterations Comments
Alzheimer's disease increased

S358-p - MLKL (human)
Modsite: ELRkTQtsMSLGTtR SwissProt Entrez-Gene
Orthologous residues
MLKL (human): S358‑p, MLKL (mouse): S345‑p, MLKL (rat): S345‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human
Comments:  double stained sections from AD patients
Downstream Regulation
Effect of modification (function):  intracellular localization, protein conformation
Comments:  colocalization of RIPK1, pMLK1, and tau phosphorylated at S202, necroptosis
Associated Diseases
Diseases Alterations Comments
Alzheimer's disease increased

S202-p - Tau iso8 (human)
Modsite: sGyssPGsPGtPGsR SwissProt Entrez-Gene
Orthologous residues
Tau (human): S519‑p, Tau iso2 (human): S144‑p, Tau iso3 (human): S108‑p, Tau iso4 (human): S173‑p, Tau iso5 (human): S202‑p, Tau iso6 (human): S144‑p, Tau iso7 (human): S173‑p, Tau iso8 (human): S202‑p, Tau (mouse): S494‑p, Tau iso3 (mouse): S191‑p, Tau iso7 (mouse): S151‑p, Tau (rat): S513‑p, Tau (cow): S209‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  Alzheimer's disease
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  human
Comments:  double stained sections from AD patients
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  colocalization of RIPK1, pMLK1, and tau phosphorylated at S202, necroptosis