Curated Information
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Home > Curated Information Page > PubMed Id: 29298849
Moszczynski AJ, et al. (2018) Pathologic Thrtau phosphorylation in CTE and CTE with ALS. Neurology 90, e380-e387 29298849
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T175-p - Tau iso8 (human)
Modsite: AtRIPAktPPAPktP SwissProt Entrez-Gene
Orthologous residues
Tau (human): T492‑p, Tau iso2 (human): T117‑p, Tau iso3 (human): T81‑p, Tau iso4 (human): T146‑p, Tau iso5 (human): T175‑p, Tau iso6 (human): T117‑p, Tau iso7 (human): T146‑p, Tau iso8 (human): T175‑p, Tau (mouse): T467‑p, Tau iso3 (mouse): T164‑p, Tau iso7 (mouse): T106‑p, Tau (rat): T486‑p, Tau (cow): T166‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', spinal cord
Cellular systems studied:  tissue
Species studied:  human, rat
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  colocalization- a subset of pThr 231 tau pathology is also pThr 175 positive
Associated Diseases
Diseases Alterations Comments
ALS, CTE increased CTE with ALS
CTE increased colocalization of pT175 tau with the active pGSK3B

T231-p - Tau iso8 (human)
Modsite: KKVAVVRtPPKsPss SwissProt Entrez-Gene
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso4 (human): T202‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', spinal cord
Cellular systems studied:  tissue
Species studied:  human, rat
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  colocalization- a subset of pThr 231 tau pathology is also pThr 175 positive
Associated Diseases
Diseases Alterations Comments
CTE increased colocalization of pT175 tau with the active pGSK3B
ALS, CTE increased CTE with ALS

Y216-p - GSK3B (rat)
Modsite: RGEPNVsyICsRyYR SwissProt Entrez-Gene
Orthologous residues
GSK3B (human): Y216‑p, GSK3B iso2 (human): Y216‑p, GSK3B (mouse): Y216‑p, GSK3B (rat): Y216‑p, GSK3B (rabbit): Y216‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', spinal cord
Cellular systems studied:  tissue
Species studied:  human, rat
Associated Diseases
Diseases Alterations Comments
TBI colocalized
CTE increased colocalization of pT175 tau with the active pGSK3B

T486-p - Tau (rat)
Modsite: ATRIPAKtTPsPKtP SwissProt Entrez-Gene
Orthologous residues
Tau (human): T492‑p, Tau iso2 (human): T117‑p, Tau iso3 (human): T81‑p, Tau iso4 (human): T146‑p, Tau iso5 (human): T175‑p, Tau iso6 (human): T117‑p, Tau iso7 (human): T146‑p, Tau iso8 (human): T175‑p, Tau (mouse): T467‑p, Tau iso3 (mouse): T164‑p, Tau iso7 (mouse): T106‑p, Tau (rat): T486‑p, Tau (cow): T166‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', spinal cord
Cellular systems studied:  tissue
Species studied:  human, rat

T542-p - Tau (rat)
Modsite: KKVAVVRtPPKsPSA SwissProt Entrez-Gene
Orthologous residues
Tau (human): T548‑p, Tau iso2 (human): T173‑p, Tau iso3 (human): T137‑p, Tau iso4 (human): T202‑p, Tau iso5 (human): T231‑p, Tau iso6 (human): T173‑p, Tau iso7 (human): T202‑p, Tau iso8 (human): T231‑p, Tau (mouse): T523‑p, Tau iso3 (mouse): T220‑p, Tau iso7 (mouse): T180‑p, Tau (rat): T542‑p, Tau (cow): T238‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'brain, hippocampus', spinal cord
Cellular systems studied:  tissue
Species studied:  human, rat