Gayrard C, et al. (2018) Src- and confinement-dependent FAK activation causes E-cadherin relaxation and β-catenin activity. J Cell Biol 217 29311227

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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Y753-p - CDH1 (human) ▲

Modsite: DDtRDNVyyyDEEGG SwissProt Entrez-Gene Orthologous residues CDH1 (human): Y753‑p, CDH1 (mouse): Y755‑p, CDH1 (rat): Y757‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Downstream Regulation Effect of modification (process):  endocytosis, induced

Y754-p - CDH1 (human) ▲

Modsite: DtRDNVyyyDEEGGG SwissProt Entrez-Gene Orthologous residues CDH1 (human): Y754‑p, CDH1 (mouse): Y756‑p, CDH1 (rat): Y758‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Downstream Regulation Effect of modification (process):  endocytosis, induced

Y755-p - CDH1 (human) ▲

Modsite: tRDNVyyyDEEGGGE SwissProt Entrez-Gene Orthologous residues CDH1 (human): Y755‑p, CDH1 (mouse): Y757‑p, CDH1 (rat): Y759‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Downstream Regulation Effect of modification (process):  endocytosis, induced

Y654-p - CTNNB1 (human) ▲

Modsite: RNEGVAtyAAAVLFR SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): Y654‑p, CTNNB1 (mouse): Y654‑p, CTNNB1 (rat): Y654‑p, CTNNB1 (rabbit): Y654‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Downstream Regulation Effect of modification (function):  intracellular localization

Y397-p - FAK (human) ▲

Modsite: sVsEtDDyAEIIDEE SwissProt Entrez-Gene Orthologous residues FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y397‑p, FAK iso2 (mouse): Y428‑p, FAK iso4 (mouse): Y397‑p, FAK iso9 (mouse): ‑, FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken): ‑ Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HGF increase PF-573228 HGF inhibit treatment-induced increase PP1 HGF inhibit treatment-induced increase

Y576-p - FAK (human) ▲

Modsite: RyMEDstyyKAsKGK SwissProt Entrez-Gene Orthologous residues FAK (human): Y576‑p, FAK iso2 (human): Y424‑p, FAK iso5 (human): Y576‑p, FAK (mouse): Y576‑p, FAK iso2 (mouse): Y607‑p, FAK iso4 (mouse): Y576‑p, FAK iso9 (mouse): ‑, FAK (rat): Y576‑p, FAK (chicken): Y576‑p, FAK iso5 (chicken): ‑ Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HGF increase PF-573228 HGF inhibit treatment-induced increase PP1 HGF inhibit treatment-induced increase

Y577-p - FAK (human) ▲

Modsite: yMEDstyyKAsKGKL SwissProt Entrez-Gene Orthologous residues FAK (human): Y577‑p, FAK iso2 (human): Y425‑p, FAK iso5 (human): Y577‑p, FAK (mouse): Y577‑p, FAK iso2 (mouse): Y608‑p, FAK iso4 (mouse): Y577‑p, FAK iso9 (mouse): ‑, FAK (rat): Y577‑p, FAK (chicken): Y577‑p, FAK iso5 (chicken): ‑ Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  MDCKII (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HGF increase PF-573228 HGF inhibit treatment-induced increase PP1 HGF inhibit treatment-induced increase