Curated Information
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Home > Curated Information Page > PubMed Id: 29358709
Gao L, et al. (2018) Tumor-derived exosomes antagonize innate antiviral immunity. Nat Immunol 29358709
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K77-ub - IRF3 (human)
Modsite: kPDLPtWkRNFRSAL SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): K77‑ub, IRF3 (mouse): K77‑ub, IRF3 (rat): K77‑ub
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), macrophage-bone marrow, MEF (fibroblast)
Cellular systems studied:  primary cells
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  ubiquitination

S173-p - IRF3 (human)
Modsite: PCPQPLRsPsLDNPt SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S173‑p, IRF3 (mouse): S171‑p, IRF3 (rat): S172‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial), macrophage-bone marrow, MEF (fibroblast)
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE MEKK2 (human) electrophoretic mobility shift, transfection of wild-type enzyme, phospho-antibody, co-immunoprecipitation, phosphopeptide analysis