Gao L, et al. (2018) Tumor-derived exosomes antagonize innate antiviral immunity. Nat Immunol 29358709

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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K77-ub - IRF3 (human) ▲

Modsite: kPDLPtWkRNFRSAL SwissProt Entrez-Gene Orthologous residues IRF3 (human): K77‑ub, IRF3 (mouse): K77‑ub, IRF3 (rat): K77‑ub Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial), macrophage-bone marrow, MEF (fibroblast) Cellular systems studied:  primary cells Species studied:  mouse Downstream Regulation Effect of modification (function):  ubiquitination

S173-p - IRF3 (human) ▲

Modsite: PCPQPLRsPsLDNPt SwissProt Entrez-Gene Orthologous residues IRF3 (human): S173‑p, IRF3 (mouse): S171‑p, IRF3 (rat): S172‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HEK293T (epithelial), macrophage-bone marrow, MEF (fibroblast) Cellular systems studied:  primary cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE MEKK2 (human) electrophoretic mobility shift, transfection of wild-type enzyme, phospho-antibody, co-immunoprecipitation, phosphopeptide analysis