Royo M, Fitzpatrick PF, Daubner SC (2005) Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity. Arch Biochem Biophys 434, 266-74 15639226

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S8-p - TH (rat) ▲

Modsite: MPTPSAPsPQPKGFR SwissProt Entrez-Gene Orthologous residues TH (human): T8‑p, TH iso2 (human): T8‑p, TH iso3 (human): T8‑p, TH iso4 (human): T8‑p, TH (mouse): S8‑p, TH (rat): S8‑p, TH (cow): S8‑p Downstream Regulation Effect of modification (function):  protein stabilization Comments:  Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable).

S19-p - TH (rat) ▲

Modsite: KGFRRAVsEQDAKQA SwissProt Entrez-Gene Orthologous residues TH (human): S19‑p, TH iso2 (human): S19‑p, TH iso3 (human): S19‑p, TH iso4 (human): S19‑p, TH (mouse): S19‑p, TH (rat): S19‑p, TH (cow): S19‑p Downstream Regulation Effect of modification (function):  protein stabilization Comments:  Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable).

S31-p - TH (rat) ▲

Modsite: KQAEAVtsPRFIGRR SwissProt Entrez-Gene Orthologous residues TH (human): S62‑p, TH iso2 (human): S58‑p, TH iso3 (human): S31‑p, TH iso4 (human): S35‑p, TH (mouse): S31‑p, TH (rat): S31‑p, TH (cow): S31‑p Downstream Regulation Effect of modification (function):  protein stabilization Comments:  Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable).

S40-p - TH (rat) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Downstream Regulation Effect of modification (function):  molecular association, regulation, protein stabilization Comments:  affinity for catecholamines in vitro, Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable).