Curated Information
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Home > Curated Information Page > PubMed Id: 14701743
Zhang J, et al. (2004) Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Mol Cell Biol 24, 708-18 14701743
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S988-p - BRCA1 (human)
Modsite: PPLFPIksFVKTKCK SwissProt Entrez-Gene
Orthologous residues
BRCA1 (human): S988‑p, BRCA1 iso6 (human): , BRCA1 iso7 (human): S988‑p, BRCA1 (mouse): S971‑p, BRCA1 (rat): S975‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HCC1937 (breast cell), U2OS (bone cell) [GR (human)]
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Chk2 (human) transfection of wild-type enzyme, transfection of inactive enzyme
Downstream Regulation
Effect of modification (function):  activity, induced