Gentile MT, et al. (2004) Mechanisms of soluble beta-amyloid impairment of endothelial function. J Biol Chem 279, 48135-42 15319431

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S117-p - eNOS (rat) ▲

Modsite: SRPTQGPsPTEQLLG SwissProt Entrez-Gene Orthologous residues eNOS (human): P118‑p, eNOS (mouse): S117‑p, eNOS (rat): S117‑p, eNOS (rabbit): P124‑p, eNOS (pig): P120‑p, eNOS (sheep): P120‑p, eNOS (cow): P120‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-aorta Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes beta-amyloid_40 increase ACh beta-amyloid_40 no effect upon treatment-induced increase Go_6976 beta-amyloid_40 inhibit treatment-induced increase ACh no change compared to control Go_6976 no change compared to control

T494-p - eNOS (rat) ▲

Modsite: TGITRKKtFKEVANA SwissProt Entrez-Gene Orthologous residues eNOS (human): T495‑p, eNOS (mouse): T494‑p, eNOS (rat): T494‑p, eNOS (rabbit): T501‑p, eNOS (pig): T497‑p, eNOS (sheep): T498‑p, eNOS (cow): T497‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-aorta Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes beta-amyloid_40 increase ACh beta-amyloid_40 no effect upon treatment-induced increase Go_6976 beta-amyloid_40 inhibit treatment-induced increase ACh no change compared to control Go_6976 no change compared to control

S1176-p - eNOS (rat) ▲

Modsite: TSRIRtQsFsLQERQ SwissProt Entrez-Gene Orthologous residues eNOS (human): S1177‑p, eNOS (mouse): S1176‑p, eNOS (rat): S1176‑p, eNOS (rabbit): S1183‑p, eNOS (pig): S1179‑p, eNOS (sheep): S1179‑p, eNOS (cow): S1179‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-aorta Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ACh increase beta-amyloid_40 ACh inhibit treatment-induced increase Go_6976 ACh no effect upon treatment-induced increase beta-amyloid_40 no change compared to control Go_6976 no change compared to control

S661-p - PKCB (rat) ▲

Modsite: QNEFAGFsYTNPEFV SwissProt Entrez-Gene Orthologous residues PKCB (human): S661‑p, PKCB iso2 (human): ‑, PKCB (mouse): S661‑p, PKCB iso2 (mouse): ‑, PKCB (rat): S661‑p, PKCB iso2 (rat): ‑, PKCB (cow): ‑ Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-aorta Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes beta-amyloid_40 increase