Curated Information
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Home > Curated Information Page > PubMed Id: 15138267
Blois JT, et al. (2004) B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta. J Biol Chem 279, 30123-32 15138267
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S133-p - CREB (mouse)
Modsite: EILsRRPsYRkILND SwissProt Entrez-Gene
Orthologous residues
CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte), B lymphocyte-spleen, Bal 17 (B lymphocyte)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Enzymes shown to modify site in vitro
Type Enzyme
KINASE p90RSK (mouse)
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
phorbol_ester anti-IgM inhibit treatment-induced increase
Go_6976 anti-IgM no effect upon treatment-induced increase
Go_6850 anti-IgM no effect upon treatment-induced increase
rottlerin anti-IgM inhibit treatment-induced increase
phorbol_ester, bryostatin_1 anti-IgM no effect upon treatment-induced increase

S32-p - IkB-alpha (mouse)
Modsite: LVDDRHDsGLDsMKD SwissProt Entrez-Gene
Orthologous residues
IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Go_6976 anti-IgM inhibit treatment-induced increase

S36-p - IkB-alpha (mouse)
Modsite: RHDsGLDsMKDEEYE SwissProt Entrez-Gene
Orthologous residues
IkB‑alpha (human): S36‑p, IkB‑alpha (mouse): S36‑p, IkB‑alpha (rat): S36‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
Cellular systems studied:  primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Go_6976 anti-IgM inhibit treatment-induced increase

S375-p - MSK1 (mouse)
Modsite: ERLFQGysFVAPsIL SwissProt Entrez-Gene
Orthologous residues
MSK1 (human): S376‑p, MSK1 (mouse): S375‑p, MSK1 (rat): S329‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  B lymphocyte-spleen, Bal 17 (B lymphocyte)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase

T562-p - p90RSK (mouse)
Modsite: AENGLLMtPCYtANF SwissProt Entrez-Gene
Orthologous residues
p90RSK (human): T573‑p, p90RSK iso2 (human): T582‑p, p90RSK (mouse): T562‑p, p90RSK iso3 (mouse): , p90RSK (rat): T573‑p, p90RSK (chicken): T590‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte), B lymphocyte-spleen, Bal 17 (B lymphocyte)
Cellular systems studied:  cell lines, primary cultured cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
rottlerin anti-IgM inhibit treatment-induced increase
phorbol_ester anti-IgM inhibit treatment-induced increase