Kim OJ, et al. (2004) The role of phosphorylation in D1 dopamine receptor desensitization: evidence for a novel mechanism of arrestin association. J Biol Chem 279, 7999-8010 14660631

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S256-p - DRD1 (rat) ▲

Modsite: NPVECAQsEssFKMS SwissProt Entrez-Gene Orthologous residues DRD1 (human): P256‑p, DRD1 (mouse): S256‑p, DRD1 (rat): S256‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes dopamine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered

S258-p - DRD1 (rat) ▲

Modsite: VECAQsEssFKMSFK SwissProt Entrez-Gene Orthologous residues DRD1 (human): S258‑p, DRD1 (mouse): S258‑p, DRD1 (rat): S258‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes dopamine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered

S259-p - DRD1 (rat) ▲

Modsite: ECAQsEssFKMSFKR SwissProt Entrez-Gene Orthologous residues DRD1 (human): S259‑p, DRD1 (mouse): S259‑p, DRD1 (rat): S259‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes dopamine increase Downstream Regulation Effect of modification (function):  receptor desensitization, altered