Curated Information
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Home > Curated Information Page > PubMed Id: 14660631
Kim OJ, et al. (2004) The role of phosphorylation in D1 dopamine receptor desensitization: evidence for a novel mechanism of arrestin association. J Biol Chem 279, 7999-8010 14660631
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S256-p - DRD1 (rat)
Modsite: NPVECAQsEssFKMS SwissProt Entrez-Gene
Orthologous residues
DRD1 (human): P256‑p, DRD1 (mouse): S256‑p, DRD1 (rat): S256‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dopamine increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered

S258-p - DRD1 (rat)
Modsite: VECAQsEssFKMSFK SwissProt Entrez-Gene
Orthologous residues
DRD1 (human): S258‑p, DRD1 (mouse): S258‑p, DRD1 (rat): S258‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dopamine increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered

S259-p - DRD1 (rat)
Modsite: ECAQsEssFKMSFKR SwissProt Entrez-Gene
Orthologous residues
DRD1 (human): S259‑p, DRD1 (mouse): S259‑p, DRD1 (rat): S259‑p
Characterization
Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
dopamine increase
Downstream Regulation
Effect of modification (function):  receptor desensitization, altered