Curated Information
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Home > Curated Information Page > PubMed Id: 15054093
Kohout TA, et al. (2004) Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J Biol Chem 279, 23214-22 15054093
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S356-p - CCR7 (human)
Modsite: QEQLRQWssCRHIRR SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): S356‑p, CCR7 (mouse): S356‑p, CCR7 (rat): S356‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GF109203X decrease

S357-p - CCR7 (human)
Modsite: EQLRQWssCRHIRRs SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): S357‑p, CCR7 (mouse): S357‑p, CCR7 (rat): S357‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GF109203X decrease

S364-p - CCR7 (human)
Modsite: sCRHIRRssMSVEAE SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): S364‑p, CCR7 (mouse): A364‑p, CCR7 (rat): T364‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GF109203X decrease

S365-p - CCR7 (human)
Modsite: CRHIRRssMSVEAEt SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): S365‑p, CCR7 (mouse): S365‑p, CCR7 (rat): S365‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GF109203X decrease

T372-p - CCR7 (human)
Modsite: sMSVEAEttttFsP_ SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): T372‑p, CCR7 (mouse): T372‑p, CCR7 (rat): T372‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL19 increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  ERK1/2 phosphorylation

T373-p - CCR7 (human)
Modsite: MSVEAEttttFsP__ SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): T373‑p, CCR7 (mouse): T373‑p, CCR7 (rat): T373‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL19 increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  ERK1/2 phosphorylation

T374-p - CCR7 (human)
Modsite: SVEAEttttFsP___ SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): T374‑p, CCR7 (mouse): T374‑p, CCR7 (rat): T374‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL19 increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  ERK1/2 phosphorylation

T375-p - CCR7 (human)
Modsite: VEAEttttFsP____ SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): T375‑p, CCR7 (mouse): T375‑p, CCR7 (rat): T375‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL19 increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  ERK1/2 phosphorylation

S377-p - CCR7 (human)
Modsite: AEttttFsP______ SwissProt Entrez-Gene
Orthologous residues
CCR7 (human): S377‑p, CCR7 (mouse): S377‑p, CCR7 (rat): S377‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CCL19 increase
Downstream Regulation
Effect of modification (function):  phosphorylation
Comments:  ERK1/2 phosphorylation