Kohout TA, et al. (2004) Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7. J Biol Chem 279, 23214-22 15054093

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S356-p - CCR7 (human) ▲

Modsite: QEQLRQWssCRHIRR SwissProt Entrez-Gene Orthologous residues CCR7 (human): S356‑p, CCR7 (mouse): S356‑p, CCR7 (rat): S356‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GF109203X decrease

S357-p - CCR7 (human) ▲

Modsite: EQLRQWssCRHIRRs SwissProt Entrez-Gene Orthologous residues CCR7 (human): S357‑p, CCR7 (mouse): S357‑p, CCR7 (rat): S357‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GF109203X decrease

S364-p - CCR7 (human) ▲

Modsite: sCRHIRRssMSVEAE SwissProt Entrez-Gene Orthologous residues CCR7 (human): S364‑p, CCR7 (mouse): A364‑p, CCR7 (rat): T364‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GF109203X decrease

S365-p - CCR7 (human) ▲

Modsite: CRHIRRssMSVEAEt SwissProt Entrez-Gene Orthologous residues CCR7 (human): S365‑p, CCR7 (mouse): S365‑p, CCR7 (rat): S365‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes GF109203X decrease

T372-p - CCR7 (human) ▲

Modsite: sMSVEAEttttFsP_ SwissProt Entrez-Gene Orthologous residues CCR7 (human): T372‑p, CCR7 (mouse): T372‑p, CCR7 (rat): T372‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CCL19 increase Downstream Regulation Effect of modification (function):  phosphorylation Comments:  ERK1/2 phosphorylation

T373-p - CCR7 (human) ▲

Modsite: MSVEAEttttFsP__ SwissProt Entrez-Gene Orthologous residues CCR7 (human): T373‑p, CCR7 (mouse): T373‑p, CCR7 (rat): T373‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CCL19 increase Downstream Regulation Effect of modification (function):  phosphorylation Comments:  ERK1/2 phosphorylation

T374-p - CCR7 (human) ▲

Modsite: SVEAEttttFsP___ SwissProt Entrez-Gene Orthologous residues CCR7 (human): T374‑p, CCR7 (mouse): T374‑p, CCR7 (rat): T374‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CCL19 increase Downstream Regulation Effect of modification (function):  phosphorylation Comments:  ERK1/2 phosphorylation

T375-p - CCR7 (human) ▲

Modsite: VEAEttttFsP____ SwissProt Entrez-Gene Orthologous residues CCR7 (human): T375‑p, CCR7 (mouse): T375‑p, CCR7 (rat): T375‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CCL19 increase Downstream Regulation Effect of modification (function):  phosphorylation Comments:  ERK1/2 phosphorylation

S377-p - CCR7 (human) ▲

Modsite: AEttttFsP______ SwissProt Entrez-Gene Orthologous residues CCR7 (human): S377‑p, CCR7 (mouse): S377‑p, CCR7 (rat): S377‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Relevant cell lines - cell types - tissues:  293 (epithelial) [CCR7 (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes CCL19 increase Downstream Regulation Effect of modification (function):  phosphorylation Comments:  ERK1/2 phosphorylation