Chiu T, Santiskulvong C, Rozengurt E (2005) EGF receptor transactivation mediates ANG II-stimulated mitogenesis in intestinal epithelial cells through the PI3-kinase/Akt/mTOR/p70S6K1 signaling pathway. Am J Physiol Gastrointest Liver Physiol 288, G182-94 15358595

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T412-p - p70S6K (human) ▲

Modsite: NQVFLGFtyVAPsVL SwissProt Entrez-Gene Orthologous residues p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin increase AG1478 angiotensin inhibit treatment-induced increase

S235-p - S6 (human) ▲

Modsite: IAKRRRLssLRAsts SwissProt Entrez-Gene Orthologous residues S6 (human): S235‑p, S6 (mouse): S235‑p, S6 (rat): S235‑p, S6 (fruit fly): A234‑p, S6 (cow): S235‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin increase AG1478 angiotensin inhibit treatment-induced increase

S236-p - S6 (human) ▲

Modsite: AKRRRLssLRAstsK SwissProt Entrez-Gene Orthologous residues S6 (human): S236‑p, S6 (mouse): S236‑p, S6 (rat): S236‑p, S6 (fruit fly): S235‑p, S6 (cow): S236‑p Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin increase AG1478 angiotensin inhibit treatment-induced increase

S473-p - Akt1 (rat) ▲

Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene Orthologous residues Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  IEC-18 (epithelial) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin increase AG1478 angiotensin inhibit treatment-induced increase

S2448-p - mTOR (rat) ▲

Modsite: RSRTRTDsYSAGQSV SwissProt Entrez-Gene Orthologous residues mTOR (human): S2448‑p, mTOR (mouse): S2448‑p, mTOR (rat): S2448‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  IEC-18 (epithelial) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes angiotensin increase rapamycin angiotensin inhibit treatment-induced increase

T412-p - p70S6K (rat) ▲

Modsite: NQVFLGFtYVAPSVL SwissProt Entrez-Gene Orthologous residues p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  IEC-18 (epithelial) Cellular systems studied:  cell lines Species studied:  rat

S235-p - S6 (rat) ▲

Modsite: IAKRRRLssLRAsts SwissProt Entrez-Gene Orthologous residues S6 (human): S235‑p, S6 (mouse): S235‑p, S6 (rat): S235‑p, S6 (fruit fly): A234‑p, S6 (cow): S235‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  IEC-18 (epithelial) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Akt2 (rat) genetic knockout/knockin of upstream enzyme KINASE Akt1 (rat) genetic knockout/knockin of upstream enzyme

S236-p - S6 (rat) ▲

Modsite: AKRRRLssLRAstsK SwissProt Entrez-Gene Orthologous residues S6 (human): S236‑p, S6 (mouse): S236‑p, S6 (rat): S236‑p, S6 (fruit fly): S235‑p, S6 (cow): S236‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  IEC-18 (epithelial) Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Akt2 (rat) genetic knockout/knockin of upstream enzyme KINASE Akt1 (rat) genetic knockout/knockin of upstream enzyme